王彦恩;刘晓凤;王红雨;高玉洁;张金林;

• 1:河北农业大学理学院
• 2:河北农业大学植物保护学院

摘要(Abstract)：

基于除草剂新靶标转酮醇酶,采用农药分子合理设计的方法,对化合物α-三联噻吩进行结构改造,以异噁唑胺为核心杂环,引入噻吩、呋喃、苯并咪唑等杂环结构,设计合成9个异噁唑胺类化合物5(a-i)。所有化合物均经~1HNMR和元素分析验证,除草活性筛选发现,含有苯并咪唑基团的5c和5f表现出较高的除草活性,在200 mg/L浓度下,对马唐和反枝苋的根茎抑制率达到90%～96%,其优于阳性对照药剂丙炔氟草胺(80%～88%),表明以异噁唑胺为先导,引入苯并咪唑基团有利于提高化合物的除草活性,且5c和5f有潜力作为除草剂候选化合物,值得进一步结构优化。

关键词(KeyWords)： 杂草抗性;转酮醇酶;分子设计;异噁唑胺类

Abstract:

Keywords:

基金项目(Foundation): 河北农业大学理工基金项目(LG201802);; 河北省大学生创新创业训练计划资助项目(s202010086035);; 国家自然科学基金资助项目(31871981);; 河北省博士后科研项目择优资助(B2019005008)

作者(Author): 王彦恩;刘晓凤;王红雨;高玉洁;张金林;

Email:

DOI: 10.13320/j.cnki.jauh.2021.0014

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